Congratulations to Franziska Lademann, PhD - 2022 Recipient of the Friedrich Heuck Osteologie Award Rewarding three of her original publications about the effects of thyroid hormones on bone, Franziska received this year’s Friedrich Heuck Osteologie Award sponsored by the Deutsche Akademie der osteologischen & rheumatologischen Wissenschaften e.V. (DAdorW). Dresden, 21.12.2022 Thyroid hormones are essential regulators of skeletal growth and bone metabolism. In her first paper „Lack of the thyroid hormone transporter Mct8 in osteoblast and osteoclast progenitors increases trabecular bone in male mice“ Franziska investigated the role of the thyroid hormone transporter [...]

April 23 is International FOP Awareness Day 2022!! Dresden, 23.04.2022 Fibrodysplasia Ossificans Progressiva (FOP) is an ultra-rare severely disabling genetic disease affecting 1 in 1.5 million people. It is characterized by excessive heterotopic ossification that progressively limits movement. Patients suffer from malformed big toes and bone formation in muscles, tendons, ligaments and other connective tissues. FOP results from mutations in the ACVR1 gene, which encodes for the BMP type I receptor ALK2. These mutations lead to hyper-responsiveness of this receptor to various ligands of the TGFb/BMP superfamily. Since the University of Pennsylvania announced [...]

Congratulations to Manuel Gado for defending his Ph.D. thesis with magna cum laude! For his doctoral studies in the field of endocrinology, Manuel investigated the interaction between glucocorticoid signaling and the sympathetic nervous system in both the skeleton and the adipose tissue. Dresden, 15.12.2021 To that end, he used two methods to activate the adaptive thermogenic capacity in mice: long-term cold acclimatization and a chronic administration of a β3-AR agonist. He demonstrated that activation of the beta-adrenergic system either with long-term cold acclimation or pharmacological β3-AR activation prevented the onset of glucocorticoid-induced adipose [...]

Congratulations to Giulia Furesi for defending her Ph.D. thesis with summa cum laude! For her doctoral studies in the osteooncology field, Giulia focused on the role of extracellular vesicles in bone-prostate cancer cell crosstalk. Dresden, 23.07.2021 Her research emphasizes the importance of tumor-derived extracellular vesicles in intercellular communication and underlines their impact on altering the physiological behavior of distant target cells, specifically osteoblasts. Moreover, Giulia’s results suggest that uptake of PCa-derived exosomal miRNAs by osteoblasts might contribute to the formation of metastatic bone lesions. This project would have not been possible without the [...]

Auszeichnung für Dresdner Knochenforscher Bei der Jahrestagung der Deutschen Gesellschaft für Endokrinologie (DGE) werden herausragende wissenschaftliche Arbeiten auf dem Gebiet der Osteologie mit dem von Recklinghausen Preis ausgezeichnet. In diesem Jahr wurde diese Ehre einem Forscherteam des Bone Lab Dresden zuteil. Dresden, 09.03.2021 Dr. med. univ. Nikolai Jaschke gelang unter der Supervision von PD Dr. Tilman Rachner und Dr. Andy Göbel der Nachweis einer neuen Funktion des Proteins Dickkopf-1 (DKK1). „Dickkopf-1 ist primär für seine Rolle in der Regulation des Knochenstoffwechsels bekannt. In unseren Untersuchungen konnten wir nun jedoch anhand klinischer Daten, Zell- [...]

FOP Germany supports the Bone Lab Dresden Dresden, 03.11.2020 Last week, we received the wonderful news that the FOP Association in Germany (www.fop-ev.de), a patient organization, will support research in the Bone Lab Dresden that is connected to heterotopic ossification and FOP. Receiving such a generous gift from FOP eV is a tremendous honor and highly motivating! We are delighted to have the support from such an active patient group! FOP is an ultra-rare disease that is characterized by excessive heterotopic ossification that progressively limits movement. All patients with FOP have a characteristic [...]

Tracing Iron  Newly funded Research Unit FerrOs studies effects of iron metabolism on bone and liver health. Professor Martina Rauner and associates receive 4.5 million Euros for DFG Research Group. Dresden, 16.10.2020 The trace element iron is essential for life. The liver is a central organ for iron homeostasis and maintains systemic iron levels in a narrow range that is optimal for human health. Iron deficiency is commonly the result of inappropriate uptake as in vegetarians or after chronic blood loss. The resulting iron-deficiency anemia is a common disease of the elderly. However, [...]