Congratulations to Manuel Gado for defending his Ph.D. thesis with magna cum laude!
For his doctoral studies in the field of endocrinology, Manuel investigated the interaction between glucocorticoid signaling and the sympathetic nervous system in both the skeleton and the adipose tissue.
To that end, he used two methods to activate the adaptive thermogenic capacity in mice: long-term cold acclimatization and a chronic administration of a β3-AR agonist. He demonstrated that activation of the beta-adrenergic system either with long-term cold acclimation or pharmacological β3-AR activation prevented the onset of glucocorticoid-induced adipose dysfunction and related metabolic comorbidities. Thus, targeting β3-AR may be regarded as a potential therapeutic strategy to prevent glucocorticoid-induced metabolic disease.
Manuel will continue working as a postdoc in Holger Henneicke’s lab focusing on the interaction between glucocorticoids and IL4 in skeletal biology at the CRTD in Dresden.
Keep up the good work, Manuel!