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Bone Lab Dresden

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Maintaining lifelong bone health remains a challenge. Therefore, our team works on several research projects linking bone research with diabetes, hematology, immunology, endocrinology, oncology, and materials science. Through our research, we expect to translate bone discoveries into more effective therapies for patients.

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Research Blog & News

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Congratulations to Manuel Gado for defending his Ph.D. thesis with magna cum laude!

For his doctoral studies in the field of endocrinology, Manuel investigated the interaction between glucocorticoid signaling and the sympathetic nervous system in both the skeleton and the adipose tissue.

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Dresden, 15.12.2021

To that end, he used two methods to activate the adaptive thermogenic capacity in mice: long-term cold acclimatization and a chronic administration of a β3-AR agonist. He demonstrated that activation of the beta-adrenergic system either with long-term cold acclimation or pharmacological β3-AR activation prevented the onset of glucocorticoid-induced adipose dysfunction and related metabolic comorbidities. Thus, targeting β3-AR may be regarded as a potential therapeutic strategy to prevent glucocorticoid-induced metabolic disease.

Manuel will continue working as a postdoc in Holger Henneicke’s lab focusing on the interaction between glucocorticoids and IL4 in skeletal biology at the CRTD in Dresden.

Keep up the good work, Manuel!

Congratulations to Giulia Furesi for defending her Ph.D. thesis with summa cum laude!

For her doctoral studies in the osteooncology field, Giulia focused on the role of extracellular vesicles in bone-prostate cancer cell crosstalk.

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Dresden, 23.07.2021

Her research emphasizes the importance of tumor-derived extracellular vesicles in intercellular communication and underlines their impact on altering the physiological behavior of distant target cells, specifically osteoblasts. Moreover, Giulia’s results suggest that uptake of PCa-derived exosomal miRNAs by osteoblasts might contribute to the formation of metastatic bone lesions. This project would have not been possible without the successful collaboration within the µBONE consortium. As her next career step, Giulia will join the lab of Professor Roberta Faccio, Washington University School of Medicine, St. Louis, USA, as a postdoc in September 2021. We are so proud of her and wish her all the best for her future scientific career!

Congratulations to Maria Ledesma Colunga and Giulia Furesi on their great achievements at the ECTS Digital Congress 2021!

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Dresden, 17.05.2021

Giulia Furesi and Maria Ledesma Colunga, both young scientists from the Dresden Bone Lab, received the opportunity to present their research on the ECTS Digital Congress 2021 in form of an oral presentation.

Giulia Furesi presented her PhD thesis work in the osteooncology field as an oral presentation in the basic/translational session: Cancer, Regeneration and Stem Cells with the title: “Extracellular vesicles from metastatic prostate cancer modulate osteoblastic functions”. Her abstract has been selected for the ECTS Travel Award.

Maria Ledesma Colunga, a Postdoc interested in osteohematology and osteimmunology, presented her latest results in the session Progress in Translational Research as a plenary oral presentation, entitled “Deletion of Transferrin Receptor 2 (Tfr2) aggravates inflammation and bone erosion by promoting macrophage activation in inflammatory arthritis”. Moreover, Maria obtained the New Investigator Award for her Abstract.

We are proud of having such highly motivated and ambitious young scientists in our Bone Lab!

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Contact

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Bone Lab Dresden
Medizinische Klinik und Poliklinik III
Universitätsklinikum Carl Gustav Carus Dresden
Phone: +49 (0)351 458-3173
eMail: info@bone-lab.de
Fetscherstraße 74 · 01307 Dresden · Germany

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