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Bone Lab Dresden

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Maintaining lifelong bone health remains a challenge. Therefore, our team works on several research projects linking bone research with diabetes, hematology, immunology, endocrinology, oncology, and materials science. Through our research, we expect to translate bone discoveries into more effective therapies for patients.

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Dr. Ulrike Baschant and Prof. Martina Rauner with FOP T-Shirts

April 23 is International FOP Awareness Day 2022!!

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Dresden, 23.04.2022

Fibrodysplasia Ossificans Progressiva (FOP) is an ultra-rare severely disabling genetic disease affecting 1 in 1.5 million people. It is characterized by excessive heterotopic ossification that progressively limits movement. Patients suffer from malformed big toes and bone formation in muscles, tendons, ligaments and other connective tissues. FOP results from mutations in the ACVR1 gene, which encodes for the BMP type I receptor ALK2. These mutations lead to hyper-responsiveness of this receptor to various ligands of the TGFb/BMP superfamily.

Since the University of Pennsylvania announced their breakthrough discovery of the FOP gene ACVR1 at April 23, 2006, this date is now celebrated as International FOP Awareness Day! This year marks the 16th anniversary of the discovery of the FOP gene meaning 16 years of hope, progress and determination to find a cure.

Martina Rauner and Ulrike Baschant, two scientists from the Bone Lab Dresden, are trying to find new therapeutic approaches to abrogate heterotopic ossification. To support the FOP community, they are also wearing T-shirts to raise awareness for the 2022 Global FOP Awareness Day.

For more information and if you wish to support the FOP community, too, please visit: https://www.ifopa.org/2022_global_awareness_day

Hope. Believe. Wish. for a future without FOP.

Congratulations to Manuel Gado for defending his Ph.D. thesis with magna cum laude!

For his doctoral studies in the field of endocrinology, Manuel investigated the interaction between glucocorticoid signaling and the sympathetic nervous system in both the skeleton and the adipose tissue.

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Dresden, 15.12.2021

To that end, he used two methods to activate the adaptive thermogenic capacity in mice: long-term cold acclimatization and a chronic administration of a β3-AR agonist. He demonstrated that activation of the beta-adrenergic system either with long-term cold acclimation or pharmacological β3-AR activation prevented the onset of glucocorticoid-induced adipose dysfunction and related metabolic comorbidities. Thus, targeting β3-AR may be regarded as a potential therapeutic strategy to prevent glucocorticoid-induced metabolic disease.

Manuel will continue working as a postdoc in Holger Henneicke’s lab focusing on the interaction between glucocorticoids and IL4 in skeletal biology at the CRTD in Dresden.

Keep up the good work, Manuel!

Congratulations to Giulia Furesi for defending her Ph.D. thesis with summa cum laude!

For her doctoral studies in the osteooncology field, Giulia focused on the role of extracellular vesicles in bone-prostate cancer cell crosstalk.

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Dresden, 23.07.2021

Her research emphasizes the importance of tumor-derived extracellular vesicles in intercellular communication and underlines their impact on altering the physiological behavior of distant target cells, specifically osteoblasts. Moreover, Giulia’s results suggest that uptake of PCa-derived exosomal miRNAs by osteoblasts might contribute to the formation of metastatic bone lesions. This project would have not been possible without the successful collaboration within the µBONE consortium. As her next career step, Giulia will join the lab of Professor Roberta Faccio, Washington University School of Medicine, St. Louis, USA, as a postdoc in September 2021. We are so proud of her and wish her all the best for her future scientific career!

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Bone Lab Dresden
Medizinische Klinik und Poliklinik III
Universitätsklinikum Carl Gustav Carus Dresden
Phone: +49 (0)351 458-3173
eMail: info@bone-lab.de
Fetscherstraße 74 · 01307 Dresden · Germany

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