Thyroid hormones control growth, shape, and accrual of bone. They are indispensable for normal bone development and homeostasis. As undiagnosed hyperthyroidism is an important risk factor for falls and osteoporotic fractures, we see a need to uncover mechanisms of bone loss associated with altered thyroid function that may translate into better bone health.
In this area, we define how thyroid hormones and their receptors affect bone biology and skeletal strength with a focus on osteocyte biology and associated pathways, including Wnt signalling. Moreover, we are interested in how thyroid hormones enter bone cells to exert their function. Using murine transgenic models as well as pharmacological-induced models of hyperthyroidism combined with translational approaches based on patient biomaterial we aim to decipher underlying mechanisms of disease and contribute to the development of tailored individualized therapies.